Defining the Plasma Methylome to Guide Melanoma Treatment.

Grant number: 105724 | Funding period: 2021 - 2025

Completed

Abstract

This project aims to characterise circulating methylation patterns (chemical modifications to DNA) from the blood of melanoma patients. Through this ground-breaking research, I will establish a minimally-invasive and simple blood test that will predict response and resistance from treatment, provide a greater understanding of the disease, reshape the treatment management of melanoma patients and lead to improved patient outcomes.

Related publications (4)

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Early circulating tumor DNA dynamics at the commencement of curative-intent radiotherapy or chemoradiotherapy for NSCLC

M MacManus, L Kirby, B Blyth, O Banks, OA Martin, MM Yeung, N Plumridge, M Shaw, F Hegi-Johnson, S Siva, D Ball, SQ Wong

2023-11-01

Background: The kinetics of circulating tumor DNA (ctDNA) release following commencement of radiotherapy or chemoradiotherapy may ..

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The landscape of cell-free mitochondrial DNA in liquid biopsy for cancer detection

Ymke van der Pol, Norbert Moldovan, Jip Ramaker, Sanne Bootsma, Kristiaan J Lenos, Louis Vermeulen, Shahneen Sandhu, Idris Bahce, D Michiel Pegtel, Stephen Q Wong, Sarah-Jane Dawson, Dineika Chandrananda, Florent Mouliere

2023-10-12

Background: Existing methods to detect tumor signal in liquid biopsy have focused on the analysis of nuclear cell-free DNA (cfDNA)..

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Detection of cell-free microbial DNA using a contaminant-controlled analysis framework

E Zozaya-Valdés, SQ Wong, J Raleigh, A Hatzimihalis, S Ftouni, AT Papenfuss, S Sandhu, MA Dawson, SJ Dawson

2021-12-01

Background: The human microbiome plays an important role in cancer. Accumulating evidence indicates that commensal microbiome-deri..

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Custom workflows to improve joint variant calling from multiple related tumour samples: FreeBayesSomatic and Strelka2Pass

S Hollizeck, SQ Wong, B Solomon, D Chandrananda, SJ Dawson

2021-11-01

This work describes two novel workflows for variant calling that extend the widely used algorithms of Strelka2 and FreeBayes to ca..

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